Joana Cristina Pacheco Barbosa

Centre for Biotechnology and Fine Chemistry (CBQF)

Joana Cristina Pacheco Barbosa

jcbarbosa@ucp.pt

PhD in Biology – Specialization Molecular Biology and Genetics – at Universidade de Aveiro in collaboration with the Technical University of Berlin and Instituto de Medicina Molecular, Lisboa. Main research areas include: natural products of bacterial origin, particularly with antibiotic bioactivity, and their characterization in terms of structure, activity, mode of action and cytotoxicity; genetic manipulation and heterologous expression of bioactive compounds of interest; antibiotic resistance spreading surveillance; probiotic strains and their biomolecular and genetic characterization; food biotechnology. Currently, PhD researcher from CAPEOSBAC project – “Tailored microenCAPsulation technology for Extreme Oxygen-Sensitive BACteria with beneficial effects in the gut microbiota: Production, stability and functionality enhancements in various carriers”, focused on: characterization of the interaction between probiotic strains and eukaryotic cells; characterization of probiotic strains delivery systems, in terms of efficacy and safety; biomolecular assessment of probiotic strains fitness when subject to different stressors; genome mining approaches for genetic characterization of probiotic strains.

 

 

Publications

Joana Barbosa, Tânia Caetano, Eva Mösker, Roderich Süssmuth, Sónia Mendo: Lichenicidin rational site-directed mutagenesis library: A tool to generate bioengineered lantibiotics. Biotechnology and Bioengineering (2019), DOI: 10.1002/bit.27130

Lopes C., Barbosa J., Maciel E., da Costa E., Alves E., Ricardo F., Domingues P., Mendo S., Domingues M.R.M.: Decoding the Fatty Acid Profile of Bacillus licheniformis I89 and Its Adaptation to Different Growth Conditions to Investigate Possible Biotechnological Applications. LIPIDS (2019), DOI: 10.1002/lipd.12142

Celestina Lopes, Joana Barbosa, Elisabete Costa, Eliana Alves, Pedro Domingues, Sónia Mendo, Rosário Domingues: Lipidomic signature of Bacillus licheniformis I89 during the different growth phases unravelled by high-resolution liquid chromatography-mass spectrometry. Archives Of Biochemistry And Biophysics (2019), DOI: 10.1016/j.abb.2018.12.024

J. Barbosa, T. Caetano, S. Mendo: Class I and Class II lanthipeptides produced by Bacillus spp., Journal of Natural Products (2015), DOI: 10.1021/np500424y

T. Caetano, J. Barbosa, E. Möesker, R.D. Süssmuth, S. Mendo: Bioengineering of lanthipeptides in E. coli: assessing the specificity of lichenicidin and haloduracin biosynthetic machinery, Research in Microbiology (2014), DOI: 10.1016/j.resmic.2014.07.006.

Researcher Center

Centre for Biotechnology and Fine Chemistry (CBQF)

Role

Post Doc

Academic CV