Maria Adelia Rodrigues Mendes

Centre for Biotechnology and Fine Chemistry (CBQF)

Maria Adelia Rodrigues Mendes

mamendes@porto.ucp.pt

I graduated in Biochemistry at the Sciences Faculty of University of Porto in 2009. After a research internship in the Molecular Pathology and Immunology Institute of University of Porto (IPATIMUP), I pursued a master’s degree in molecular Oncology at the Biomedical Sciences Institute Abel Salazar (ICBAS) and the Portuguese Oncology Institute (IPO-Porto). There, I studied genetic alterations in parathyroid tumors. After that, I worked for three years as a research fellow in IPATIMUP, where I studied the impact of low-dose radiation on disease development, especially in atherosclerosis. In 2015 I moved to Brussels to pursue my PhD, in the Université Libre de Bruxelles (ULB) during which I studied the impact of rare chromosomal translocations in nuclear pore proteins in aggressive subtypes of acute myeloid and lymphoid leukemias. I joined Amyris Bio Products Portugal and the Alchemy project in August 2020. Currently, I am responsible for managing the cell culture lab and, together with my team colleagues, for performing biological assays that are integrated into the product development cycle by the Alchemy team.

 

 

Publications

Adélia Mendes, Ramona Juhlen, Valérie Martinelli and Birthe Fahrenkrog, Targeted CRM1 inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements, 2020, Oncotarget. DOI.: 10.18632/oncotarget.27711

Adélia Mendes, Ramona Juhlen, Sabrina Bousbata and Birthe Fahrenkrog, Disclosing the interactome of leukemogenic NUP98-HOXA9 and SET-NUP214 fusion proteins using a proteomic approach, 2020, Cells. DOI.: 10.3390/cells9071666

Adélia Mendes, and Birthe Fahrenkrog, NUP214 in leukemia: It’s more than transport, 2019, Cells, DOI.: 10.3390/cells8010076 Nuno Martins, Adélia Mendes (co-first author) and Birthe Fahrenkrog, On the effects of leukemogenic nucleoporin fusion proteins on nucleocytoplasmic transport and gene expression, 2018 Book Series: Nuclear-Cytoplasmic Transport, ISBN 978- 3-319-77308-7

Port S.A., Mendes A., Valkova C., Spilner C. Fahrenkrog B., Kaether C., and Kehlenbach R., The oncogenic fusion proteins SET-NUP214 and Sequestosome 1(SQSTM1)-NUP214 form dynamic nuclear bodies and differentially affect nuclear protein and poly(A)+ RNA export, 2016, Journal of Biological Chemistry, DOI.: 10.1074/jbc.M116.735340

Is Low-Dose Radiation Exposure a Risk Factor for Atherosclerotic Disease? Boaventura P, Durães C, Mendes A, Costa NR, Chora I, Ferreira S, Araújo E, Lopes P, Rosa G, Marques P, Tavares S, Chaves V, Bettencourt P, Oliveira I, Costa F, Ramos I, Teles MJ, Guimarães JT, Sobrinho-Simões M, Soares P., 2018, Radiation Research, DOI.: 10.1667/RR14942.1

Researcher Center

Centre for Biotechnology and Fine Chemistry (CBQF)

Researcher type

Post Doc

Academic CV