Computational microbiology – from extreme environments to biotechnology

Tuesday, November 09, 2021 - 17:30

A talk by Lukasz Dziewit, Professor at the University of Warsaw (Department of Environmental Microbiology and Biotechnology), Poland. Please register here.

The development of sequencing technologies resulted in a tremendous progress in microbial ecology (including microbiology of extreme environments) and environmental biotechnology. It is directly related to the technological and conceptual leap in bioinformatics, which has become one of the most dynamically developing fields of biology. However, in environmental researches, and in particular in environmental microbiology, there is still a lot to be discovered and optimized, especially when analyzing data, coupling them with metadata and developing novel tools for studying microbial biodiversity. In our researches, we focused on genomic analyzes of plasmidomes and metaplasmidomes of extreme environments, identifying genes of an adaptive value and analyzing the range of horizontal gene/plasmid transfer. In addition, thanks to in-depth genomic analysis of psychrotolerant bacteria, we managed to create biological systems that use selected strains as microbial factories for producing various secondary metabolites (dyes, siderophores and surfactants), which then we used for producing novel environmental technologies. An important aspect of our research is also the development of novel tools (including bioinformatic ones) for environmental analyses. We developed a set of novel primers for screening of antibiotic resistance genes; LCPDb-ARG - literature-based, manually-curated database of PCR primers for the monitoring of antibiotic resistance genes in various environments and MAISEN – the system for semiautomatic annotation of bacterial genomes.

Moderation: Ivone Moreira