Silk sericin-based hydrogel: a novel biomaterial for wound healing

Friday, October 29, 2021 - 14:15

Entre em no dia 29 de outubro de 2021 às 14h15 e assista à Biotalk (em inglês) de Sara Baptista Silva. A "entrada" é livre e gratuita, sem necessidade de inscrição.



In situ cross-linked hydrogels have the advantage of effectively fulfilling the wound in its shape and depth for proper clinical use. Amongst the new generation of natural-based biopolymers being proposed for wound care and skin regeneration, silk sericin is particularly interesting due to its exceptional properties (i.e. biocompatibility, biodegradability, anti-inflammatory and antioxidant), being also a textile industry by-product and an environment contaminant. Hereupon, a novel in situ enzyme-mediated cross-linked hydrogel composed of silk sericin was performed via horseradish peroxidase, in a simple, fast, and practical in situ forming approach to produce a biomaterial able to be applied in low exudative chronic wounds. The achievements in a diabetic wound healing animal model granted its protection effect against oxidative stress, while controlling inflammation, promoting healing and fast tissue regeneration.