Ana Leite Oliveira

Centre for Biotechnology and Fine Chemistry (CBQF)

Ana Leite Oliveira

aloliveira@ucp.pt

Ana Leite Oliveira holds a PhD from the University of Minho (in 2008), collaborating with Depuy Orthopaedics,Inc. (Johnson&Johnson), USA and CSIC, Madrid, followed by a Post-Doc partnering with Tufts University, Boston, USA. She gained expertise in biomaterials for tissue regeneration, working presently in skin-related applications. She has published over 70 international peer reviewed articles and book chapters and participated in more than 100 international scientific and technological conferences, mostly as an oral presenter or as an invited lecturer. The innovation in her work generated 5 patents and links to industry, working with companies to reach new products/processes. She successfully prepared/coordinated various projects funded by National/European agencies and private companies.

Presently she is the head of the Biomaterials and Biomedical Technology Laboratory at CBQF and Assistant Professor at Escola Superior de Biotecnologia, Universidade Católica Portuguesa, responsible for courses in the Master of Biomedical Engineering and Bachelors’ Degree in Bioengineering. Since 2008 she has been assisting the European Commission as an Independent Expert for the Research Executive Agency (REA) in several actions, such as Marie Skłodowska-Curie actions (H2020, FP7), Cost Actions and FET OPEN Calls. Presently, she is Vice-chair for the FET OPEN programme, while also monitoring ongoing FET OPEN projects, in the role of Innovation Radar and as Technical Monitor.

 

 

Publications (2017-2021)

Patents:

Oliveira AL, Silva SB, Borges SC, Alves PJ, Silk Sericin-based Hydrogel, Methods and Uses Thereof, Patent number 20161000045461 (2016); WO/2018/011732 (2018); US20190224374A1 (2021).

San Roman J, Vasquez BM, Garcia LF, Barbosa AM, Gomes F, Oliveira AL, Activators for the crosslinking of polysaccharides and proteins with antioxidant activity, P201730794 (2018).

 

Papers in international peer-reviewed journals:

Duarte MM, Silva VI; Eisenhut, Bionda A, Duarte AR, Oliveira AL, Contributions of Supercritical Fluid Technology for Advancing Decellularization and Postprocessing of Viable Biological Material. Materials Horizons (2021) 2022 Mar 7;9(3):864-891. https://doi.org/10.1039/D1MH01720A.

Veiga A, Magalhães R, Duarte MM, Dias JR, Alves NM, Costa-Pinto AR, Castro F, Rocha F, Oliveira AL. Continuous Production of Highly Tuned Silk/Calcium-Based Composites: Exploring New Pathways for Skin Regeneration. Molecules. 2022 Mar 30;27(7):2249. https://doi.org/10.3390/molecules27072249.

Zou S, Fan S, Oliveira AL, Yao X, Zhang Y, Shao H. 3D Printed Gelatin Scaffold with Improved Shape Fidelity and Cytocompatibility by Using Antheraea pernyi Silk Fibroin Nanofibers. Advanced Fiber Materials. 2022 Mar 1:1-6. https://doi.org/10.1007/s42765-022-00135-w.

Baptista-Silva SI, Borges SC, Brassesco ME, Coscueta ER, Oliveira AL, Pintado MM. Research, develoment and future trends for medical textile products. Medical textiles from natural resources. 2022 Jun 1;3(1st):1-45.

Veiga A, Silva IV, Duarte MM and Oliveira AL, Current trends on protein driven bioinks for 3D printing, Pharmaceutics. 2021 Pharmaceutics 2021, 13(9), 1444; (IF: 6,321) https://doi.org/10.3390/pharmaceutics13091444

Bernardes BG, Del Gaudio P, Alves P, Costa R, García-Gonzaléz CA, Oliveira AL. Bioaerogels: Promising Nanostructured Materials in Fluid Management, Healing and Regeneration of Wounds. Molecules. 2021; 26(13):3834. (IF 3.267) https://doi.org/10.3390/molecules26133834

Baptista-Silva S, Borges S, Costa-Pinto AR, Costa R, Amorim M, Dias JR, Ramos Oì, Alves P, Granja PL, Soares R, Pintado M, Oliveira AL. In Situ Forming Silk Sericin-Based Hydrogel: A Novel Wound Healing Biomaterial. ACS Biomaterials Science and Engineering. 2021 (IF 4.152)7, 4; 10.1021/acsbiomaterials.0c01745

Duarte MM, Ribeiro N, Silva IV, Dias JR, Alves NM, Oliveira AL. Fast Decellularization Process Using Supercritical Carbon Dioxide for Trabecular Bone. The Journal of Supercritical Fluids. 2021 Feb 16:105194. https://doi.org/10.1016/j.supflu.2021.105194.

Guimarães I, Baptista-Silva S, Pintado M, Oliveira AL. Polyphenols: A Promising Avenue in Therapeutic Solutions for Wound Care. Applied Sciences. 2021 Jan;11(3):1230. https://doi.org/10.3390/app11031230.

Dias J.R., Oliveira da Silva S., Ribeiro N., Batista da Silva Sara, Costa-Pinto A.R., Alves N., Oliveira AL, In Situ Enabling Approaches For Tissue Regeneration: Current Challenges And New Developments, Frontiers in Bioengineering and Biotechnology, 2020, 8:85 DOI: 10.3389/fbioe.2020.00085.

Veiga A., Castro F., Rocha F, Oliveira AL Recent advances in silk sericin/calcium phosphate biomaterials. Frontiers in Materials. 2020; 7:24. doi: 10.3389/fmats.2020.00024.
Ribeiro N., Soares G.C., Santos-Rosales V., Concheiro A., Alvarez-Lorenzo C., García-González C.A. and Oliveira A.L, 2020, A new era for sterilization based on supercritical CO2 technology, Journal of Biomedical Materials Research: Part B - Applied Biomaterials.

Veiga A, Castro F, Reis CC, Sousa A, Oliveira AL, Rocha F. Hydroxyapatite/sericin composites: A simple synthesis route under near-physiological conditions of temperature and pH and preliminary study of the effect of sericin on the biomineralization process. Materials Science and Engineering: C. 2020 Mar 1;108:110400. doi.org/10.1016/j.msec.2019.110400.
Veiga A, Castro F, Rocha F, Oliveira AL. Protein-Based Hydroxyapatite Materials: Tuning Composition toward Biomedical Applications. ACS Applied Bio Materials. 2020, 3, 6, 3441–3455. doi.org/10.1021/acsabm.0c00140.

Best MG, Cunha-Reis C, Ganin AY, Sousa A, Johnston J, Oliveira AL, Smith DG, Yiu HH, Cooper IR. Antimicrobial Properties of Gallium (III)-and Iron (III)-Loaded Polysaccharides Affecting the Growth of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, In Vitro. ACS Applied Bio Materials. 2020 Oct 12. doi.org/10.1021/acsabm.0c00811.

Silva SC, Braz EM, Brito CA, Alves MM, Carvalho FA, Barreto HM, Oliveira AL, Silva DA, Silva-Filho EC. Phthalic anhydride esterified chicha gum: characterization and antibacterial activity. Carbohydrate Polymers. 2020 Sep 13;251:117077.

Veiga A, Castro F, Oliveira AL, and Rocha F. "High efficient strategy for the production of hydroxyapatite/silk sericin nanocomposites." Journal of Chemical Technology & Biotechnology (2020). DOI 10.1002/jctb.6532.

Braz EM, Silva SC, Brito CA, Carvalho FA, Alves MM, Barreto HM, Silva DA, Magalhães R, Oliveira AL, Silva-Filho EC. Modified chicha gum by acetylation for antimicrobial and antiparasitic applications: Characterization and biological properties. International Journal of Biological Macromolecules. 2020 May 29. doi.org/10.1016/j.ijbiomac.2020.05.219.

Santos MV, Oliveira AL, Osajima JA, Silva-Filho EC. Development of composites scaffolds with calcium and cerium-hydroxyapatite and gellan gum. Ceramics International. 2020 Feb 15;46(3):3811-7.

Santos-Rosales V., Ardao I., Alvarez-Lorenzo C., Ribeiro N., Oliveira AL*, García-González C.A., Sterile and dual-porous aerogels scaffolds obtained through a multistep supercritical CO2-based approach, Molecules 24.5 (2019): 871.

Ribeiro N., Soares G.C., Santos-Rosales V., Concheiro A., Alvarez-Lorenzo C., García-González C.A. and Oliveira AL, 2019, A new era for sterilization based on supercritical CO2 technology, Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 2019.

Geão, C., Costa-Pinto, A.R., Cunha-Reis, C., Ribeiro, V.P., Vieira, S., Oliveira, J.M., Reis, R.L. and Oliveira, A.L., 2019. Thermal annealed silk fibroin membranes for periodontal guided tissue regeneration. Journal of Materials Science: Materials in Medicine, 30(2), p.27.

Serôdio R., Schickert S.L., Costa-Pinto A.R., Dias J.R., Granja P.L., Yang F., and Oliveira AL, 2019. Ultrasound sonication prior to electrospinning tailors silk fibroin/PEO membranes for periodontal regeneration. Materials Science and Engineering: C. Volume 98, May 2019, p. 969-981.

Soares G.C., Learmonth D.A., Vallejo M.C., Davila S.P., González P., Sousa R.A. and Oliveira AL, 2019. Supercritical CO2 technology: The next standard sterilization technique?. Materials Science and Engineering: C, Volume 99, June 2019, p. 520-540.

Ribeiro V., Pina S., Costa J.B., Cengiz I.F., García-Fernández L., Fernández-Gutiérrez M.D.M., Paiva O.C., Oliveira AL, San Roman, J., Oliveira, J.M. and Reis, R.L., 2019. Enzymatically crosslinked silk fibroin-based hierarchical scaffolds for osteochondral regeneration. ACS applied materials & interfaces. 2019, 11 (4), pp 3781–3799. DOI: 10.1021/acsami.8b21259.

Dias J.R., Baptista-Silva S., Sousa A., Oliveira AL, Bártolo P.J. and Granja P.L., 2018. Biomechanical performance of hybrid electrospun structures for skin regeneration. Materials Science and Engineering: C, 93, pp.816-827.

Ribeiro V.P., da Silva Morais A., Maia F.R., Canadas R.F., Costa J.B. Oliveira, A.L., Oliveira J.M. and Reis, R.L., 2018. Combinatory approach for developing silk fibroin scaffolds for cartilage regeneration. Acta biomaterialia, 72, pp.167-181.doi:10.1016/j.actbio.201.03.047, 2018.

Ribeiro V. P., Silva-Correia J., Gonçalves C., Pina S., Radhouani H., Hyttinen J., Roy A., Oliveira AL, Reis R. L., and Oliveira J. M., Rapidly responsive silk fibroin hydrogels as an artificial matrix for the programmed tumor cells death, PLoS ONE, vol. 13, issue 4, pp. e0194441, doi:10.1371/journal.pone.0194441, 2018.

Dias, J.R., Baptista-Silva, S., de Oliveira, C.M.T., Sousa, A., Oliveira AL, Bártolo P.J. and Granja, P.L., 2017. In situ crosslinked electrospun gelatin nanofibers for skin regeneration. European Polymer Journal, 95, pp.161-173.

Ribeiro VP, Silva-Correia J, Nascimento AI, daSilva Morais A, Marques AP, Ribeiro AS, Silva C, Bonifácio G, Sousa RA, Oliveira JM, Oliveira AL, Reis RL, Complex 3D Biotextiles for Flat BoneTissue Engineering Applications, Biomaterials, Biomaterials, Volume 123, April 2017, Pages 92–106. IF: 8.978.

 

 

Research Lab: Biomaterials and Biomedical Technology

Role

Assistant Professor

Academic CV